Association Between Periodontitis and Amyloid beta Peptide in Elderly People With and Without Cognitive Impairment

作者：Antonio Gil Montoya Jose; Barrios Rocio; Santana Soraya; Sanchez Lara Ines; Carnero Pardo Cristobal; Fornieles Rubio Francisco; Montes Juan; Ramirez Carlos; Angel Gonzalez Moles Miguel; Burgos Javier S

来源：Journal of Periodontology, 2017, 88(10): 1051-1058.

DOI：10.1902/jop.2017.170071

• Amyloid beta-peptides
• cognitive dysfunction
• dementia
• oral health
• periodontal diseases.

Background: Evidence that periodontal disease is a possible risk factor for cognitive impairment may be explained by the inflammatory hypothesis. The aim of this study is to determine whether periodontitis is related to the amyloid beta(Ab) load in blood and the role of any such relationship in the association between Ab and cognitive impairment.
Methods: A case-control study was performed in elderly people diagnosed with cognitive impairment with or without dementia (cases group) and cognitively healthy elderly people (control group); data were collected on the medical and dental history of participants, and blood samples were drawn to determine Ab levels using enzyme-linked immunosorbent assay.
Results: The study included 166 patients and 122 control participants. Higher blood A beta(1-42) levels (P = 0.01) and higher A beta(42:40) ratio (P = 0.06) were observed in participants with severe attachment loss than in other participants. Periodontitis was a significant interaction variable, given that the association between A beta(1-42) and A beta(1-40) and cognitive impairment was only observed in patients with severe periodontitis. According to these data, periodontitis may be a modulating variable of the association between Ab and cognitive impairment.
Conclusions: Plasma A beta(1-42) levels are higher in individuals who have severe periodontal disease. The presence of periodontitis may modify the association between Ab and cognitive impairment.

• 出版日期2017-10