Availability, price and affordability of anti-tuberculosis drugs in Europe: a TBNET survey

作者：Guenther Gunar; Gomez Gabriela B; Lange Christoph; Rupert Stephan; van Leth Frank^*

来源：European Respiratory Journal, 2015, 45(4): 1081-1088.

DOI：10.1183/09031936.00124614

Data on availability and cost of anti-tuberculosis (TB) drugs in relation to affordability at national level are scarce.
We performed a cross-sectional study on availability and cost of anti-TB drugs at major TB-reference centres in 37 European countries. Costs of standardised treatment regimens used for pan-sensitive TB, multidrug-resistant (MDR) TB, pre-extensively drug-resistant (XDR) TB, and XDR-TB were compared using a purchasing power analysis. Affordability was evaluated in relation to monthly national gross domestic products per capita (GDP).
At least one second-line injectable and either moxifloxacin or levofloxacin were available in all countries. Linezolid and clofazimine were available in 79% and 46% of the countries, respectively. Drug cost for XDR-TB was three-times more expensive than those for MDR-TB. The average price of treatment for pan-sensitive TB represented a maximum of 8.5% of the monthly GDP across countries, while for standard MDR-TB treatment this was <30% in only six countries and more than 100% in four countries. Treatment of XDR-TB represented more than 100% of a month's GDP in all countries where the regimen was available.
High cost and limited availability of drugs for treatment of drug-resistant TB, particularly beyond resistance to first-line drugs, are a major impediment to successful TB control in Europe.

• 出版日期2015-4