New Cytotoxic Metabolites from a Deep-Sea-Derived Fungus, Phialocephala sp., Strain FL30r

作者：Li, De-Hai; Cai, Sheng-Xin; Zhu, Tian-Jiao; Wang, Feng-Ping; Xiao, Xiang; Gu, Qian-Qun^*

来源：Chemistry and Biodiversity, 2011, 8(5): 895-901.

DOI：10.1002/cbdv.201000134

• NATURAL-PRODUCTS
• BISORBICILLINOIDS
• DERIVATIVES

Two new sorbicillinoids, 1 and 2, together with a novel benzofuranone derivative named phialofurone (3), were isolated from a deep-sea sediment-derived fungus, Phialocephala sp. Their structures were established on the basis of spectroscopic data. All compounds displayed cytotoxic effects against P388 (IC(50) values of 11.5 +/- 1.4, 0.1 +/- 0.1, and 0.2 +/- 0.01 mu M, resp.) and K562 (IC(50) values of 22.9 +/- 0.8, 4.8 +/- 0.3 and 22.4 +/- 0.9 mu M, resp.) cell lines.

• 出版日期2011-5
• 单位中国海洋大学; 上海交通大学