The synthesis of peptide fragments of high affinity receptor FcE > RI and their binding to allergen-specific immunoglobulins E

作者：Gribovskaya O V^*; Martinovich V P; Golubovich V P; Yanchenko V V; Vykhristenko L R; Novikov D K

来源：Russian Journal of Bioorganic Chemistry, 2012, 38(3): 253-260.

DOI：10.1134/S1068162012030041

• immunobiological activity
• immunoglobulin E
• peptide synthesis
• receptor Fc epsilon RI

Using computer analysis, a minimal sequence of Arg136-Asn137-Trp138-Asp139 that can bind to IgE C3 and C4 fragments was determined for the high-affinity receptor FcE > RI, a key protein of IgE-dependent allergic reactions of the immediate type. A number of peptides containing the Arg-Asn-Trp-Asp sequence were proposed as model analogues of the FcE > RI receptor. It was shown that these peptides manifested immunobiological effects and bound to IgE. The peptides were demonstrated to bind to IgE serum antibodies specific to the Dermatophagoides pteronyssinus allergen isolated from plasma of patients with allergic bronchial asthma.

• 出版日期2012-5