Dosimetric evaluation of MLC-based dynamic tumor tracking radiotherapy using digital phantom: Desired setup margin for tracking radiotherapy

作者：Kadoya Noriyuki^*; Ichiji Kei; Uchida Tomoya; Nakajima Yujiro; Ikeda Ryutaro; Uozumi Yosuke; Zhang Xiaoyong; Bukovsky Ivo; Yamamoto Takaya; Takeda Ken; Takai Yoshihiro; Jingu Keiichi; Homma Noriyasu

来源：Medical Dosimetry, 2018, 43(1): 74-81.

DOI：10.1016/j.meddos.2017.08.005

• Radiotherapy
• Dynamic tumor tracking radiotherapy
• Setup margin
• Four-dimensional dose calculation
• Stereotactic body radiotherapy

The purpose of this study is to evaluate the dosimetric impact of the margin on the multileaf collimator-based dynamic tumor tracking plan. Furthermore, an equivalent setup margin (EM) of the tracking plan was determined according to the gated plan. A 4-dimensional extended cardiac-torso was used to create 9 digital phantom datasets of different tumor diameters (TDs) of 1, 3, and 5 cm and motion ranges (MRs) of 1, 2, and 3 cm. For each dataset, respiratory gating (30% to 70% phase) and tumor tracking treatment plans were prepared using 8-field 3-dimensional conformal radiation therapy by 4-dimensional dose calculation. The total lung V20 was calculated to evaluate the dosimetric impact for each case and to estimate the EM with the same impact on lung V20 obtained with the gating plan with a setup margin of 5 mm. The EMs for (TD = 1 cm, MR = 1 cm}, {TD = 1 cm, MR = 2 cm}, and {TD = 1 cm, MR = 3 cm} were estimated as 5.00, 4.16, and 4.24 mm, respectively. The EMs for (TD = 5 cm, MR = 1 cm}, (TD = 5 cm, MR = 2 cm}, and {TD = 5 cm, MR = 3 cm} were estimated as 4.24 mm, 6.35 mm, and 7.49 mm, respectively. This result showed that with a larger MR, the EM was found to be increased. In addition, with a larger TD, the EM became smaller. Our result showing the EMs provided the desired accuracy for multileaf collimator-based dynamic tumor tracking radiotherapy.

• 出版日期2018