Mitochondrial ryanodine receptors and other mitochondrial Ca2+ permeable channels

作者：Ryu Shin Young; Beutner Gisela; Dirksen Robert T; Kinnally Kathleen W; Sheu Shey Shing^*

来源：FEBS LETTERS, 2010, 584(10): 1948-1955.

DOI：10.1016/j.febslet.2010.01.032

• Ca2+ channel
• Mitochondrial Ca2+ uniporter (MCU)
• Mitochondrial ryanodine receptor (mRyR)
• Rapid mode Ca2+ uptake (RaM)
• Ruthenium red
• Ru360
• Ryanodine

Ca2+ channels that underlie mitochondrial Ca2+ transport first reported decades ago have now just recently been precisely characterized electrophysiologically. Numerous data indicate that mitochondrial Ca2+ uptake via these channels regulates multiple intracellular processes by shaping cytosolic and mitochondrial Ca2+ transients, as well as altering the cellular metabolic and redox state. On the other hand, mitochondrial Ca2+ overload also initiates a cascade of events that leads to cell death. Thus, characterization of mitochondrial Ca2+ channels is central to a comprehensive understanding of cell signaling. Here, we discuss recent progresses in the biophysical and electrophysiological characterization of several distinct mitochondrial Ca2+ channels.

• 出版日期2010-5-17