Allergies to biologicals: Epidemiological data

作者：Demoly P^*

来源：Revue Francaise d'Allergologie, 2009, 49(3): 264-271.

DOI：10.1016/j.reval.2009.01.008

• Biologicals
• Chemotherapeutic agents
• Adverse reactions
• Drug allergy
• Epidemiology

More and more biological chemotherapeutic agents are available on the drug market. Adverse reactions to these agents have recently been classified into five different subtypes. Some of these adverse effects, including allergic reactions, are potentially life-threatening. Hypersensitivity reactions to these products correspond to beta-type reactions in this classification. In this review, we analyse the data concerning the most frequently used biologicals, with a special focus on TNF alpha antagonists, as they represent a dramatic improvement in the prognosis of both rheumatic and inflammatory bowel diseases. Certain reports on patients with reactions induced by omalizumab and by cetuximab, which are relatively frequent, are very instructive. Most of the other publications on this subject are case reports with allergic reactions, very few of which were properly investigated or well-documented.

• 出版日期2009-4