Manometric Measurement of the Sphincter of Oddi in Patients with Common Bile Duct Stones: A Consecutive Study of the Han Population of China

作者：Feng, Yadong; Zhang, Jie; Jiao, Chunhua; Zhu, Hong^*; Cheng, Wenfang; Xu, Shunfu; Xiao, Bin; Ni, Jinliang; Chen, Xiaoxing^*

来源：Gastroenterology Research and Practice, 2017, 2017: 9031438.

DOI：10.1155/2017/9031438

• PERIAMPULLARY DUODENAL DIVERTICULA
• ENDOSCOPIC SPHINCTEROTOMY
• BILIARY MANOMETRY
• RISK-FACTORS
• GALLSTONES
• COMPLICATIONS
• DYSFUNCTION
• PRESSURE
• DISEASE
• SIZE

Objective. Role of dysfunction of the sphincter of Oddi (SO) in choledocholithiasis is controversial. This study was to evaluate SO motor activity in patients with common bile duct (CBD) stones in the Han population of China. Patients and Methods. In this study, 76 patients with CBD stones were enrolled in a single tertiary endoscopy center. Data of SO motor activities was prospectively evaluated by endoscopic manometry. Mean basal SO pressure, amplitude, and frequency were collected and analyzed. Results. The mean basal SOpressure, amplitude, and frequency were 52.7 +/- 40.0 (1.60-171.1) mmHg, 39.9 +/- 19.7 (14.9-115.5) mmHg, and 5.7 +/- 3.2 (1.3-13.8)/min, respectively. The basal SO pressure was higher in patients with CBD stones < 10mm in diameter than that in those withCBD stones larger than 10mm in diameter (60.7 +/- 41.0 mmHg versus 36.8 +/- 29.4 mmHg, p = 0.043). There was no significant difference in the basal SO pressure, amplitude, and frequency when compared with the CBD diameter, CBD stone number, prior cholecystectomy, periampullary diverticula, and symptoms. Levels of alanine aminotransferase, aspartate transaminase, gamma-glutamyl transpeptidase, and alkaline phosphatase showed no significant difference in patients with normal or elevated basal SO pressure. Conclusion. These results identify that, in Chinese Han population, abnormalities of SO motor activity are associated with CBD stones.

• 出版日期2017
• 单位南京医科大学; 东南大学