Novel 3D composites with highly flexible behavior based on chitosan and bioactive glass for biomedical applications

作者：Martins Talita^*; Oliveira Agda A R; Oliveira Ana Celeste; Boaventura Tulio P; Barrioni Breno R; Costa Junior Ezequiel S; Pereira Marivalda M

来源：Materials Chemistry and Physics, 2017, 189: 1-11.

DOI：10.1016/j.matchemphys.2016.12.012

• Biocomposite
• Biomaterial
• Scaffolds
• Flexible foam
• Chitosan
• Bioactive glass

Scaffolds with a 3D cellular solid structure have been studied intensively for tissue engineering. These materials should have adequate porosity, appropriate pore size, interconnectivity, and mechanical behavior compatible with the features of native tissue, allowing cell activities. In this work, novel flexible 3D composite foams of chitosan (CH) combined with bioactive glass (BG) in 1:0 and 1:1 ratios by a foaming method were developed. Physical characterization was performed by FOR, XRD, SEM and micro CT, where as mechanical features were evaluated by static compression and constant deflection compression tests. Resazurin assay was used to assess the cytotoxicity. Both scaffolds obtained presented a highly porous structure with interconnectivity. Our results revealed that CH/BG foams presented increased mechanical properties, probably as a result of greater intermolecular interaction and a more homogeneous pore size and distribution, and permitted a shape recovery greater than 80% of the original shape after 12 h of constant compression. The composites did not produce toxic effects. Therefore, the introduction of the inorganic phase into the chitosan matrix had a crucial effect on the morphologic and mechanical response of the flexible composite foams. These materials may be potential alternative scaffolds for tissue regeneration and stimulation of healing.

• 出版日期2017-3-1