Neuroprotective bakkenolides from the roots of Valeriana jatamansi

作者：Xu Jing; Yang Bo; Guo Yuanqiang^*; Jin Da qing; Guo Ping; Liu Cuizhou; Hou Wenbin; Zhang Tiejun; Gui Liping; Sun Zhanping

来源：Fitoterapia, 2011, 82(6): 849-853.

DOI：10.1016/j.fitote.2011.04.012

• Valeriana jatamansi
• Bakkenolide
• Neuroprotective effect
• MPP(+)
• Sesquiterpene

Two new bakkenolides, valerilactones A (1), and B (2), and two known analogues, bakkenolide-H (3) and bakkenolide-B (4), were isolated from the roots of Valeriana jatamansi. Their structures and relative configurations were elucidated by spectroscopic methods (IR, ESIMS, HRESIMS, 1D and 2D NMR) and by comparison of their NMR data with those of related compounds. Compounds 1, 2, and 3 exhibited potent neuroprotective effects against MPP(+)-induced neuronal cell death in human dopaminergic neuroblastoma SH-SY5Y cells.

• 出版日期2011-9
• 单位哈尔滨商业大学; 天津药物研究院有限公司; 南开大学