Arsenic trioxide induced endoplasmic reticulum stress in laryngeal squamous cell line Hep-2 cells

作者：Yang Xinxin; An Liangxiang; Li Xiaoyu^*

来源：Auris Nasus Larynx, 2014, 41(1): 81-83.

DOI：10.1016/j.anl.2013.06.001

• Arsenic trioxide
• Hep-2
• Endoplasmic reticulum stress
• GRP78
• CHOP

Arsenic trioxide (As2O3) has been used in the treatment of acute promyelocytic leukemia (APL) and many malignant solid tumors. Recently, endoplasmic reticulum (ER) stress plays an important role in As2O3-treated laryngeal squamous cell line Hep-2 cells. In the present work, the expression of ER stress-related proteins was investigated in As2O3-treated Hep-2 cells. The results showed that As2O3 increased the expression of GRP78, CHOP, phosphorylated eIF2 alpha and ATF4, all of which are the molecule of ER stress. Therefore, As2O3 induced ER stress in Hep-2 cells.

• 出版日期2014-2
• 单位济宁医学院