Association of MMP-2 polymorphisms with occurrence risk of stroke

作者：Zhang, Li; Ren, Runan^*; Mu, Shaoning

来源：International Journal of Clinical and Experimental Pathology, 2016, 9(2): 2215-2221.

• MMP-2
• polymorphism
• stroke
• interaction

Aims: This study was designed to discuss the association between matrix metalloproteinase-2 (MMP-2) gene C-735T, C-1306T polymorphisms and stroke, meanwhile, to detect the interaction of MMP-2 polymorphisms in stroke. Methods: In 95 patients with stroke and 120 healthy controls, who were matched in age and gender, polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to determine the genotypes of C-735T and C-1306T polymorphisms. The distribution differences of genotypes and alleles between the case and control groups were tested by chi-square. Odds ratio (OR) and 95% confidence interval (CI) were applied to express the relative risk of stroke. Crossover analysis was conducted to check the interaction of MMP-2 polymorphisms. Results: In MMP-2 C-735T polymorphism, both of TT genotype and T allele showed the significant frequency difference between the case and control groups (P<0.05), which indicated the carriers easily suffered from stroke (OR=3.26, 95% CI=1.07-9.90; OR=1.68, 95% CI=1.06-2.68). Similarly, the CT genotype and T allele in C-1306T polymorphism had statistically significant difference between two groups (P<0.05) and they might be associated with the onset risk of stroke (OR=2.83, 95% CI=1.20-6.70; OR=3.89, 95% CI=1.77-8.55). In addition, these two polymorphisms of MMP-2 gene had the strong interaction. Conclusion: MMP-2 C-735T and C-1306T polymorphisms are related to the occurrence risk of stroke and both of two play a role in stroke synergistically.

• 出版日期2016
• 单位聊城市人民医院