Anionic chlorido(triphenyl) tin(IV) bearing N-phthaloylglycinato or 1,2,4-benzenetricarboxylato 1,2-anhydride ligands: potential cytotoxic and apoptosis-inducing agents against several types of cancer

作者：Huebner Denise; Kaluderovic Milena R; Gomez Ruiz Santiago; Kaluderovic Goran N^*

来源：Chemical Biology & Drug Design, 2017, 89(4): 628-633.

DOI：10.1111/cbdd.12885

• apoptosis
• cell cycle
• cytotoxicity
• DNA laddering
• organotin(IV) compounds

Two ionic triphenyltin(IV) chloride carboxylate compounds of the formula [NHEt3] [Ph3SnCl(L)] [LH = N-phthaloylglycine (P-GlyH), 1; 1,2,4-benzenetricarboxylic 1,2-anhydride (BTCH), 2] were tested for the in vitro activity against 518A2 (melanoma), FaDu (head and neck carcinoma), HT-29 (colon cancer), MCF-7 (breast carcinoma), and SW1736 (thyroid cancer) cell lines. The ammonium salts of the carboxylic acids are found to be not active, while anionic [Ph3SnCl(L)]-exhibited high cytotoxicity in nM range, both higher activity and selectivity than cisplatin. Compounds 1 and 2 are inducing apoptosis, which was proved with the morphological and biochemical features such as membrane blebbing, translocation of phosphatidylserine, and DNA fragmentation. Thus, accumulation of cells in sub-G1 phase is observed. Both anionic organotin(IV) compounds showed potent cytotoxic and apoptotic properties against five cancer cell lines of various histogenetic origin.

• 出版日期2017-4