A Wireless Bio-MEMS Sensor for C-Reactive Protein Detection Based on Nanomechanics

作者：Chen Chun Hao; Hwang Rong Zhang; Huang Long Sun; Lin Shi Ming; Chen Hsiao Chin; Yang Yu Che; Lin Yu Tso; Yu Shih An; Lin Yo Sheng; Wang Yiao Hong; Chou Nai Kuan; Lu Shey Shi^*

来源：IEEE Transactions on Biomedical Engineering, 2009, 56(2): 462-470.

DOI：10.1109/TBME.2008.2003262

• Analog-to-digital converter (ADC)
• antiCRP
• amplitude-shift-keying (ASK) receiver
• ASK transmitter
• C-reactive protein (CRP)
• microcantilever
• label-free
• microcontrol unit (MCU)
• poly-dimethyl-siloxane (PDMS)

A quick wireless label-free detection of disease-related C-reactive proteins (CRPs) using a 200-mu m-long micro-electromechanical systems (MEMS) microcantilever housed in a 7 x 7 mm(2) reaction chamber with a safe reusable feature is reported. The assay time ranges from about 30 min to 3 h, depending on accuracy. The deflection of the microcantilever due to specific CRP-antiCRP binding is detected using a position-sensitive detector. The converted bio-signal is transmitted by a custom designed wireless amplitude-shift-keying (ASK) transceiver IC fabricated in a 0.18 mu m CMOS process. CRP concentrations from 1 mu g/mL to 500 mu g/mL can be detected. A 0.2-Hz I-V ac signal instead of traditional bases/acids is applied to the bio-MEMS sensor to unbind the CRP from the microcantilever for reusability.

• 出版日期2009-2
• 单位中国科学院电工研究所