At-Risk Alcohol Use is Associated with Antiretroviral Treatment Nonadherence Among Adults Living with HIV/AIDS

作者：Paolillo Emily W; Gongvatana Assawin; Umlauf Anya; Letendre Scott L; Moore David J^*

来源：Alcoholism: Clinical and Experimental Research , 2017, 41(8): 1518-1525.

DOI：10.1111/acer.13433

• HIV
• AIDS
• At-Risk Drinking
• Adherence
• Antiretroviral Therapy

BackgroundAlcohol use is a risk factor for nonadherence to antiretroviral therapy (ART) among people living with HIV/AIDS (PLWHA); however, differences in ART adherence across levels of alcohol use are unclear. This study examined whether at-risk alcohol use, defined by National Institute of Alcohol Abuse and Alcoholism guidelines, was associated with ART nonadherence among PLWHA.
MethodsParticipants were 535 HIV-infected adults enrolled in studies at the HIV Neurobehavioral Research Program. ART nonadherence was identified by either self-reported missed dose or plasma viral load detectability (50copies/ml). Potential covariates for multivariable logistic regression included demographics, depression, and substance use disorders.
ResultsUsing a stepwise model selection procedure, we found that at-risk alcohol use (OR=0.64; p=0.032) and low education (OR=1.09 per 1year increase in education; p=0.009) significantly predict lower ART adherence.
ConclusionsA greater focus on the treatment of at-risk alcohol use may improve ART adherence among HIV-infected persons.

• 出版日期2017-8