Amelioration of EAE by a cryptic epitope of myelin oligodendrocyte glycoprotein

作者：Lyons Jeri A; Riter Melissa M; Almatrook Alaa M; Ram**ottom Michael J; Cross Anne H

来源：Journal of Neuroimmunology, 2016, 300: 66-73.

DOI：10.1016/j.jneuroim.2016.06.006

• Experimental autoimmune encephalomyelitis
• Myelin oligodendrocyte glycoprotein
• B cells
• Antibody
• T cell epitopes
• Immune regulation

Previous work demonstrated that EAE induced by recombinant human MOG was B cell-dependent. Data presented here reveal a T cell response to MOG61-85 in human rMOG-immunized B cell(-/-) mice not observed in WT mice. Further study revealed this peptide to be a cryptic epitope in WT mice. Co-immunization of B cell(-/-) mice with M0G35-55 and MOG61-85 peptides led to less severe disease compared to mice immunized with MOG35-55 alone. Disease amelioration was associated with decreased production of Interferon-gamma by lymph node cells. Thus, MOG61-85 represents a protective epitope to human rMOG induced EAE in B cell(-/-) mice.

• 出版日期2016-11-15