科研之友
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摘要
A facile total synthesis of three members of the bisabolane sesquiterpene family, namely (+/-)-curcumene, (+/-)-xanthorrhizol and (+/-)-curcuhydroquinone had been achieved in high overall yield. The synthesis used bromobenzene derivatives as starting materials. The halogen-lithium exchange followed by addition of isoprenylacetone and reduction of the obtained carbinols are the key steps of the synthetic pathway. This synthetic approach provides a new route to the bisabolane sesquiterpenes.
