Anti-Inflammatory Activity of Chitooligosaccharides in Vivo

作者：Fernandes Joao C^*; Spindola Humberto; de Sousa Vanessa; Santos Silva Alice; Pintado Manuela E; Malcata Francisco Xavier; Carvalho Joao E

来源：Marine Drugs, 2010, 8(6): 1763-1768.

DOI：10.3390/md8061763

• chitooligosaccharides
• anti-inflammatory
• animal model

All the reports to date on the anti-inflammatory activity of chitooligosaccharides (COS) are mostly based on in vitro methods. In this work, the anti-inflammatory activity of two COS mixtures is characterized in vivo (using balb/c mice), following the carrageenan-induced paw edema method. This is a widely accepted animal model of acute inflammation to evaluate the anti-inflammatory effect of drugs. Our data suggest that COS possess anti-inflammatory activity, which is dependent on dose and, at higher doses, also on the molecular weight. A single dose of 500 mg/kg b.w. weight may be suitable to treat acute inflammation cases; however, further studies are needed to ascertain the effect upon longer inflammation periods as well as studies upon the bioavailability of these compounds.

• 出版日期2010-6