The glucagon receptor antagonist BI-32169 constitutes a new class of lasso peptides

作者：Knappe Thomas A; Linne Uwe; Xie Xiulan^*; Marahiel Mohamed A

来源：FEBS Letters, 2010, 584(4): 785-789.

DOI：10.1016/j.febslet.2009.12.046

• Lasso peptide
• Glucagon receptor antagonist
• Mass fragmentation
• NMR structure
• Disulfide bond formation
• Protein scaffold

The glucagon receptor antagonist BI-32169, recently isolated from Streptomyces sp., was described as a bicyclic peptide, although its primary structure comprises conserved elements of class I and class II lasso peptides. Tandem mass spectrometric and nuclear magnetic resonance spectroscopic studies revealed that BI-32169 is a lasso-structured peptide constituting the new class III of lasso peptides. The determined lasso fold opens new avenues to improve the promising biological activity of BI-32169.

• 出版日期2010-2-19