A design for automatic preparation of highly concentrated Re-188-perrhenate solutions

作者：Luo Tsai Yueh; Lo Ai Ren; Hsieh Bor Tsung^*; Lin Wuu Jyh

来源：Applied Radiation and Isotopes, 2007, 65(1): 21-25.

DOI：10.1016/j.apradiso.2006.03.016

• Re-188-perrhenate
• concentration yield

Rhenium-188 is extremely suitable for the radiotherapy of balloon dilation for the coronary artery restenosis. To satisfy the need of highly concentrated Re-188-perrhenate for the clinical applications, we designed an apparatus to achieve the purpose of concentrating Re-188-perrhenate solution. This apparatus comprised of a concentrator, a control box and a computer with an automatic control program. A column of cation-exchange resin in Ag+ form and an anion-exchange column in series were used in the concentration procedure. More than 90% of Re-188 isotope in the original solution could be collected with 1 mL of 0.9% NaCl solution added to collect the Re-188 adsorbed in the column in this final process (90.7 +/- 2.2%, n = 15). We also found that the radiochemical purity in the final solution remained unchanged (100%). The designed process could automatically increase the quality and efficiency of the production of highly concentrated rhenium-188 solution, and could also reduce the radiation dose absorbed by the operator.

• 出版日期2007-1