Photodynamic antifungal activities of nanostructured fabrics grafted with rose bengal and phloxine B against Aspergillus fumigatus

作者：Kim Joo Ran; Michielsen Stephen^*

来源：Journal of Applied Polymer Science, 2015, 132(26): 42114.

DOI：10.1002/app.42114

• biomedical applications
• biomaterials
• nanostructured polymers
• photochemistry
• textiles

This study demonstrates that nanostructured fabrics grafted with rose bengal (RB) and phloxine B (PB) have photodynamic antifungal effects on Aspergillus fumigatus. RB and PB were attached to vinyl benzyl chloride, and, subsequently, this was polymerized with acrylic acid and styrene sulfonic acid to produce long, water-soluble polymers to attach to the fabric surface. This gave high grafting yield and photodynamic antifungal activity against A. fumigatus. In RB and PB microdilution tests, there was no visible turbidity at 63 mu mol/L. When polymerized RB and PB were incorporated into fabrics, the actions of polymerized RB and PB resulted in less hyphal growth and germination of conidia on A. fumigatus than the free RB and PB dyes. Nanostructured fabrics created by bonding RB- or PB-containing polymers to electrospun nylon mats exhibited higher concentrations of the dyes, equivalent to 86 mu mol/L. The microstructured fabrics created by bonding RB- or PB-containing polymers to spunbonded nylon nonwoven fabrics only exhibited the equivalent of 32 mu mol/L of the dyes. The nanostructured fabrics had a specific surface area of 28.1 m(2)/g, whereas the microfabric had 1.5 m(2)/g. Thus, the nanostructured fabrics increased the surface area 18.7x and the reflectance percent 16.2x when compared with the microstructured fabrics. This resulted in much higher photodynamic antifungal activity against A. fumigatus.

• 出版日期2015-7-10