Antioxidant and antidiabetic activity of Dangyuja (Citrus grandis Osbeck) extract treated with Aspergillus saitoi

作者：Kim Gyo Nam; Shin Jung Geun; Jang Hae Dong^*

来源：Food Chemistry, 2009, 117(1): 35-41.

DOI：10.1016/j.foodchem.2009.03.072

• Dangyuja extract
• Antioxidant activity
• ORAC
• Antidiabetic activity
• Rat intestinal alpha-glucosidase inhibition

Dangyuja is a citrus fruit of Cheju Island in Korea, which is known to have a high content of flavanone glycosides, such as naringin and neohesperidin. Flavanone glycosides of Dangyuja (Citrus grandis Osbeck) extract were converted into their aglycones by naringinase and hesperidinase, and into their hydroxylated forms by Aspergillus saitoi. Dangyuja extract treated with A. saitoi had significantly higher antioxidant and antidiabetic activity than both its glycosides and aglycones in oxygen radical absorption capacity (ORAC) and supercoiled DNA strand scission assay, rat intestinal alpha-glucosidase and porcine pancreatic alpha-amylase inhibition, suggesting that the fermentation of flavanone aglycones of Dangyuja extract with A. saitoi can increase antioxidant and antidiabetic activity, compared to their glycosides and aglycones. This result suggests that Dangyuja extract prepared with enzymatic and microbial treatments could be used for the development of pharmaceutical foods to control the blood glucose level of diabetic patients by inhibiting alpha-amylase and alpha-glucosidase in the intestinal tract.

• 出版日期2009-11-1