Association between BDNF-196 G %26gt; A and BDNF-270 C %26gt; T polymorphisms, BDNF concentration, and rTMS-supported long-term rehabilitation outcome after ischemic stroke

作者：Mirowska Guzel Dagmara; Gromadzka Grazyna; Seniow Joanna; Lesniak Marcin; Bilik Marta; Waldowski Konrad; Gruchala Katarzyna; Czlonkowski Andrzej; Czlonkowska Anna^*

来源：NeuroRehabilitation, 2013, 32(3): 573-582.

DOI：10.3233/NRE-130879

• Aphasia
• brain-derived neurotrophic factor (BDNF)
• hand paresis
• ischemic stroke
• rehabilitation
• repetitive transcranial magnetic stimulation (rTMS)

BACKGROUND: The efficacy of rehabilitation in ischemic stroke patients likely varies because of brain plasticity. One of the main neurotrophins in the central nervous system is brain-derived neurotrophic factor (BDNF). %26lt;br%26gt;OBJECTIVES: This study aimed to determine allelic and genotypic distribution of BDNF-196 G%26gt;A and -270 C%26gt;T polymorphisms, and to assess the impact of repetitive transcranial magnetic stimulation (rTMS) on serum BDNF concentrations measured before rehabilitation, after the first 6 h of rehabilitation, and after 3 weeks of rehabilitation. %26lt;br%26gt;METHODS: Twenty-six patients with hand paresis and 20 with aphasia were randomly assigned to treatment with rTMS or sham stimulation (placebo group). %26lt;br%26gt;RESULTS: In men with aphasia, after the first 6 h of rTMS-supported rehabilitation, BDNF concentration was lower among rTMS-treated patients than placebo-treated patients. A similar difference was observed in women with aphasia after 3 weeks of rTMS-supported rehabilitation. No significant differences in serum BDNF concentration were observed in patients with different BDNF-196 G%26gt;A or -270 C%26gt;T genotypes. During the observation period, BDNF concentration did not differ significantly between patients who improved and those who did not. %26lt;br%26gt;DISCUSSION: One possible explanation for the observed difference between rTMS-stimulated and sham-stimulated patients is the suppression of BDNF production by rTMS in the healthy brain hemisphere.

• 出版日期2013