A facile sp(3) C-H bonds amidation of N,N-dimethylanilines by a novel ionic iron(III) complex containing an imino-functionalized imidazolium cation

作者：Zhu, Fan; Lu, Bing; Sun, Hongmei^*; Shen, Qi

来源：Tetrahedron Letters, 2016, 57(37): 4152-4156.

DOI：10.1016/j.tetlet.2016.07.098

• Iron(III) complex
• Imidazolium salts
• Amidation of C-H bond
• N,N-Dimethylanilines

A new imino-functionalized imidazolium salt, 1-[1-(2,6-diisopropylphenylimino)ethyl]-3-benzylimidazolium chloride ([HL]Cl,), was designed and used to prepare a novel ionic iron(III) complex [HL][FeCl4] (2). Complex 2 was an efficient and easy-to-use catalyst for the direct sp(3) C-H bond amidation of N,N-dimethylanilines, affording a wide variety of N-substituted aromatic or aliphatic amides in moderate to good yields. This reaction is the first example of iron-catalyzed intermolecular amidation of unactivated sp(3) C-H bonds of tertiary amines by aromatic or aliphatic amides under mild reaction conditions.

• 出版日期2016-9-14
• 单位苏州大学