Associations between Alzheimer's Disease and Blood Homocysteine, Vitamin B12, and Folate: A Case-Control Study

作者：Chen, Hui; Liu, Shuai; Ji, Lu; Wu, Tianfeng; Ma, Fei; Ji, Yong; Zhou, Yuying; Zheng, Miaoyan; Zhang, Meilin; Huang, Guowei^*

来源：Current Alzheimer Research, 2015, 12(1): 88-94.

DOI：10.2174/1567205012666141218144035

• Activities of daily living
• Alzheimer's disease
• folate
• homocysteine
• mini-Mental state examination
• vitamin B-12

Background: There is a growing focus on nutritional therapy for Alzheimer's disease (AD), and controversy exists regarding the association between AD and homocysteine (Hcy), vitamin B-12, and folate levels. Objective: The present study evaluated the association between AD and the combined levels of Hcy, vitamin B-12, and folate. Methods: This case-control study consisted of 115 patients with AD and 115 matched controls. Serum folate and vitamin B-12 were measured using an automated immunoassay analyzer. Plasma Hcy was measured using high-performance liquid chromatography. The association between AD and Hcy, vitamin B-12, and folate was analyzed using binary logistic regression, adjusted for age and sex. Results: With the combination of normal blood Hcy, vitamin B-12, and folate levels as the reference category, low vitamin B-12 in subjects with normal Hcy and folate was associated with AD (adjusted odds ratio [OR], 4.6; 95% confidence interval [CI]: 1.6-13.2). The combination of low vitamin B12 and folate in subjects with normal Hcy was associated with AD (adjusted OR, 4.3; 95% CI: 1.3-14.6). The combination of high Hcy and low folate levels in patients with normal vitamin B-12 was associated with AD (adjusted OR, 17.0; 95% CI: 5.4-53.4). The combination of high Hcy, low vitamin B-12, and any folate level was associated with AD (adjusted OR, 30.5; 95% CI: 9.7-95.9). Conclusion: Vitamin B-12 was directly associated with AD. The combination of high Hcy, low vitamin B-12, and any folate level represented the poorest association with AD.

• 出版日期2015
• 单位天津医科大学