Convenient synthesis of 12-methyl[1]benzoxepino[3,4-b]quinolin-13(6H)-ones

作者：Wang, Yu; Chang, Mingqin; Zhang, Hong; Li, Yang^*

来源：Chemistry of Heterocyclic Compounds, 2018, 54(6): 650-657.

DOI：10.1007/s10593-018-2322-y

• 1-benzoxepin-5-one
• hybrid molecule
• 4-methylquinoline
• Friedel-Crafts cyclization
• one-pot synthesis

In this work, a construction of 12-methyl[1]benzoxepino[3,4-b]quinolin-13(6H)-ones, structurally intriguing hybrid molecules consisting of fused 4-methylquinoline and 1-benzoxepin-5-one units, has been successfully achieved via a two-step procedure, involving the onepot synthesis of 2-(aryloxymethyl)-4-methylquinoline-3-carboxylic acids followed by their intramolecular Friedel-Crafts cyclization reaction. Our synthetic protocol described here could be attractive as it is simple, easy to handle and does not involve the use of expensive reagents or catalysts.

• 出版日期2018-6
• 单位渤海大学