Antioxidant, cytotoxicity, protein kinase inhibition and antibacterial activities of Fragaria x ananassa leaves

作者：Khan Ihsan; Tabassum Saira; Tofeeq-ur-Rehman; Ikram Muhammad; ul Haq Ihsan; Zia Muhammad^*

来源：Pakistan Journal of Pharmaceutical Sciences, 2018, 31(4): 1423-1429.

• Fragaria x ananassa leaves extracts
• antioxidant
• DPPH
• antibacterial
• protein kinase
• cytotoxicity

Fragaria x ananassa leaves extracts prepared in different solvents were subject for antioxidative, cytotoxicity, protein kinase inhibition and antibacterial activities. The extracts showed varying activities depending upon solvent used for extraction. Combined effect of methanol and ethyl acetate showed maximum antioxidant and reducing power potential (207.65 +/- 6 mu g AAE/mg and 88.58 +/- 20 mu g AAE/mg, respectively). Maximum DPPH (2,2-diphenyl-1-picrylhydrazyl) free radical scavenging activity was calculated by when methanol: chloroform and acetate fractions were used (87.68% and 86.88% inhibition, respectively). Total phenolics varied from 186 to 1.91 mu g AAE/mg while total flavonoids also significantly varied among the extracts. The extracts also showed significant activities against brine shrimp larvae and bacterial strains tested. The study concludes that Fragaria x ananassa leaves can be a good source for isolation of active phytochemicals to be used in different industries.

• 出版日期2018-7