Asymmetric amplification in the catalytic enantioselective 1,2-addition of Grignard reagents to enones

作者：Caprioli Francesca; Madduri Ashoka V R; Minnaard Adriaan J^*; Harutyunyan Syuzanna R

来源：Chemical Communications, 2013, 49(48): 5450-5452.

DOI：10.1039/c3cc41892h

Large asymmetric amplification originating from solubility differences between the enantiopure and the racemic catalyst is observed in the addition of Grignard reagents to enones. This behaviour is not reaction or catalyst specific and is observed for metal complexes of a variety of chiral diphosphine ligands, extensively used in asymmetric catalysis.

• 出版日期2013