Association between PD-L1 expression and driven gene status in NSCLC: A meta-analysis

作者：Li, D.; Zhu, X.^*; Wang, H.; Li, N.

来源：European Journal of Surgical Oncology, 2017, 43(7): 1372-1379.

DOI：10.1016/j.ejso.2017.02.008

• PD-L1
• Non-small cell lung cancer
• Driven genes
• Meta-analysis

Purpose: We explored the potential clinical association between programmed death-ligand 1 (PD-L1) expression and driven gene status in non-small cell lung cancer (NSCLC).
Methods: We systemically searched through October 2015. Odd ratios (ORs) with 95% CIs were calculated to examine the association of PD-L1 expression with driven gene status. A random- or fixed-effects model was used.
Results: Nine studies were identified. KRAS-mutant tumors were more likely to be PD-L1 positive than KRAS-wild type tumors (51% vs 36%; OR 1.69; 95% CI 1.01-2.84; p = 0.045). In contrast, PD-L1 expression did not differ by EGFR (OR 0.86; 95% CI 0.43-1.73; p = 0.675) or ALK (OR 1.02; 95% CI 0.44-2.37; p = 0.954) status. In subgroup analysis, there was also no significant association between PD-Ll expression and EGFR status in term of the cut-offs or ethnicity.
Conclusion: In conclusion, NSCLC with KRAS mutations showed a trend for higher frequency of positive PD-Ll expression.

• 出版日期2017-7
• 单位南方医科大学