Dynamic Hydrogels: Switching of 3D Microenvironments Using Two-Component Naturally Derived Extracellular Matrices

作者：Gillette Brian M; Jensen Jacob A; Wang Meixin; Tchao Jason; Sia Samuel K^*

来源：Advanced Materials, 2010, 22(6): 686-+.

DOI：10.1002/adma.200902265

This article describes fabrication of a two-component extracellular matrix (ECM) in which one component acts as a stable structural element and another component gels or dissolves reversibly (a modulatory component). Using a composite collagen-alginate ECM, reversible cross-linking of the alginate (the modulatory component) via application of calcium or citrate modulates cell mobility in a 3D collagen matrix (the structural component)

• 出版日期2010-2-9