A base-controlled chemoselective transfer hydrogenation of alpha, beta-unsaturated ketones catalyzed by [IrCp*Cl-2](2) with 2-propanol

作者：Chen, Shu-jie; Lu, Guo-ping; Cai, Chun^*

来源：RSC Advances, 2015, 5(17): 13208-13211.

DOI：10.1039/c5ra00484e

• ALPHA,BETA-UNSATURATED KETONES
• PRIMARY ALCOHOLS
• CONJUGATE REDUCTION
• CARBONYL-COMPOUNDS
• ALKYLATION
• PALLADIUM
• COMPLEXES
• ALKENES
• SURFACE
• ENONES

A simple homogeneous catalyst system based on commercially available [IrCp*Cl-2](2) has been developed for the conjugate reduction of alpha, beta-unsaturated ketones. Under the optimized conditions, a wide range of alpha, beta-unsaturated ketones were reduced to saturated ketones in 83-98% yield. While switching the base from K2CO3 to KOH, saturated alcohols was selectively obtained.

• 出版日期2015
• 单位南京理工大学