A small molecule that induces assembly of a four way DNA junction at low temperature

作者:Howell Lesley A; Waller Zoe A E; Bowater Richard; O'Connell Maria; Searcey Mark*
来源:Chemical communications, 2011, 47(29): 8262-8264.
DOI:10.1039/c1cc12922h

摘要

Small molecules that induce the formation of higher order DNA structures have potential therapeutic and nanotechnology applications. Screening of a click library has identified the first compound to induce the formation of a Holliday junction structure at room temperature without the need for a high temperature annealing step.

  • 出版日期2011