Mitochondrial permeability transition and oxidative stress

作者：Kowaltowski AJ; Castilho RF; Vercesi AE^*

来源：FEBS LETTERS, 2001, 495(1-2): 12-15.

DOI：10.1016/S0014-5793(01)02316-X

• mitochondrion
• calcium
• reactive oxygen
• free radical
• thiol
• cell death

Mitochondrial permeability transition (MPT3) is a non-selective inner membrane permeabilization that may precede necrotic and apoptotic cell death, Although this process has a specific inhibitor, cyclosporin ri, little is known about the nature of the proteinaceous pore that results in MPT. Here, we review data indicating that MPT is not a consequence of the opening of

• 出版日期2001-4-20