科研之友
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摘要
Background: In persons with prior paralytic poliomyelitis, progressive muscle weakness can occur after a stable period of at least 15 years. Knowledge is limited about which factors influence changes in lower limb muscle strength in these persons. Objective: To assess changes in lower limb muscle strength annually over 4 years in persons with late effects of polio and to identify prognostic factors for changes in muscle strength. Design: A prospective, longitudinal study. Setting: University hospital outpatient program. Participants: Fifty-two ambulant persons (mean age +/- standard deviation: 64 +/- 6 years) with verified late effects of polio. Methods: Mixed linear models were used to analyze changes in muscle strength and to identify determinants among the following covariates: gender, age, age at acute polio infection, time with late effects of polio, body mass index, and estimated baseline muscle weakness. Main Outcome Measurements: Knee extensor and flexor and ankle dorsiflexor muscle strength were measured annually with a Biodex dynamometer. Results: The men (n = 28) had significant linear change over time for all knee muscle strength measurements, from -1.4% (P <.05) per year for isokinetic knee flexion in the less-affected lower limb to -4.2% (P < .001) for isokinetic knee extension in the more-affected lower limb, and for 2 ankle dorsiflexor muscle strength measurements (-3.3%-1.4% per year [P <. 05]). The women (n = 24) had a significant linear change over time only for ankle dorsiflexor measurements (4.0%-5.5% per year [P <. 01]). Gender was the strongest factor that predicted a change in muscle strength over time. Conclusions: Over 4 years, men had a greater decline in muscle strength than did women, but the rate of decline did not accelerate. This finding indicates that gender could be a contributing factor to the progressive decline in muscle strength in persons with late effects of polio.
- 出版日期2015-11
