Mechanochemical preparation and pharmacological activities of water-soluble intermolecular complexes of arabinogalactan with medicinal agents

作者：Dushkin A V; Meteleva E S; Tolstikova T G; Tolstikov G A; Polyakov N E; Neverova N A; Medvedeva E N; Babkin V A

来源：Russian Chemical Bulletin, 2008, 57(6): 1299-1307.

• water-soluble complexes
• mechanochemistry
• arabinogalactan
• Sibazon(=Diazepam)
• Mezapam(=Medazepam)
• Indometacin
• Azaleptin(=Clozapine)
• pharmacological properties
• NMR relaxation in solutions

A possibility of mechanochemical preparation of water-soluble complexes of a plant polysaccharide arabinogalactan and poorly soluble medicinal agents (Sibazon(=Diazepam), Mezapam(=Medazepam), Indometacin, and Azaleptin(=Clozapine)) has been investigated. Their molecular dynamics (NMR relaxation method in solution) and some pharmacological properties have been studied in comparison with the original pharmaceutical drugs.

• 出版日期2008-6