Antigen-specific tolerance strategies for the prevention and treatment of autoimmune disease

作者:Miller Stephen D*; Turley Danielle M; Podojil Joseph R
来源:Nature Reviews Immunology, 2007, 7(9): 665-677.
DOI:10.1038/nri2153

摘要

The development of safe and effective antigen-specific therapies is needed to treat patients with autoimmune diseases. These therapies must allow for the specific tolerization of self-reactive immune cells without altering host immunity to infectious insults. Experimental models and clinical trials for the treatment of autoimmune disease have identified putative mechanisms by which antigen-specific therapies induce tolerance. Although advances have been made in the development of efficient antigen-specific therapies, translating these therapies from bench to bedside has remained difficult. Here, we discuss the recent advances in our understanding of antigen-specific therapies for the treatment of autoimmune diseases.