Hg2+ mediated quinazoline ensemble for highly selective recognition of Cysteine

作者：Anand Thangaraj; Sivaraman Gandhi; Chellappa Duraisamy^*

来源：Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy , 2014, 123: 18-24.

DOI：10.1016/j.saa.2013.12.054

• Quinazoline
• Hg2+
• Cysteine
• Quenching
• ON-OFF
• Real sample analysis

A fluorimetric sensor for Hg2+ ion and Cysteine based on quinazoline platform was designed and synthesized by one step reaction and characterized by using common spectroscopic methods. Time Dependent Density Functional Theory calculations shows that probe behaves as "ON-OFF" fluorescent quenching sensor via electron transfer/heavy atom effect. Receptor was found to exhibit selective fluorescence quenching behavior over the other competitive metal ions, and also the receptor-Hg2+ ensemble act as an efficient "OFF-ON" sensor for Cysteine. Moreover this sensor has also been successfully applied to detection of Hg2+ in natural water samples with good recovery.

• 出版日期2014-4-5