Non-Gaussian noise-optimized intracellular cytosolic calcium oscillations

作者：Gong, Yubing^*; Xie, Yanhang; Lin, Xiu; Hao, Yinghang

来源：Biosystems, 2011, 103(1): 13-17.

DOI：10.1016/j.biosystems.2010.09.006

• Non-Gaussian colored noise
• Intracellular calcium oscillations
• Coherence resonance
• Stochastic dynamics

We have numerically studied the effect of a particular kind of non-Gaussian colored noise (NGN), characterized by the deviation q from Gaussian noise (q = 1), on intracellular cytosolic calcium (Ca(2+)) oscillations. It is found that, as q is increased, the Ca(2+) oscillation regularity increases and reaches a best performance at an optimal q, and then decreases with further increasing q, which represents the occurrence of coherence resonance, i.e., the most regular Ca(2+) oscillations. Similar phenomena occur for different values of noise intensity and correlation time of the NGN. This phenomenon of deviation-optimized Ca(2+) oscillations show that, external non-Gaussian noises of different types can enhance and even optimize the intracellular Ca(2+) oscillations. This result provides new insights into the constructive roles and potential applications of non-Gaussian noises in intracellular cytosolic Ca(2+) oscillations.

• 出版日期2011-1
• 单位鲁东大学