A common polymorphism of CYP4A11 is associated with blood pressure in a Chinese population

作者：Zhang, Rong; Lu, Jingyi; Hu, Cheng; Wang, Congrong; Yu, Weihui; Ma, Xiaojing; Bao, Yuqian; Xiang, Kunsan; Guan, Youfei; Jia, Weiping^*

来源：Hypertension Research, 2011, 34(5): 645-648.

DOI：10.1038/hr.2011.8

• CYP4A11
• single nucleotide polymorphism
• Chinese

Variants of the human CYP4A11, which belongs to the cytochrome P450, family 4, have been reported to be associated with hypertension in general populations. However, data in the Chinese population are limited. This study sought to assess the effect of CYP4A11 on the prevalence of hypertension and blood pressure in a Chinese population. Three tagging single nucleotide polymorphisms, rs9332982, rs4660980 and rs3890011, were genotyped in 1734 community-based participants. Individuals with secondary hypertension were excluded. Sex-pooled and sex-specific analysis for genotype-phenotype association were both conducted. We found rs9332982 T allele was nominally associated with higher prevalence of hypertension in women after adjustment for covariates (OR: 1.38, 95% CI: 1.06-1.81, P=0.0183). The significance did not retain after Bonferroni correction. In blood pressure analysis restricted to normotensive individuals, rs4660980 was associated with both systolic (beta=-3.17, P=0.0011) and diastolic blood pressure (beta=-1.75, P=0.0010) in men. A common variant on CYP4A11 was associated with blood pressure in a Chinese population. Future studies are needed to confirm our findings. Hypertension Research (2011) 34, 645-648; doi:10.1038/hr.2011.8; published online 17 February 2011

• 出版日期2011-5
• 单位北京大学; 上海市临床检验中心; 上海交通大学