Abietane diterpenoids from Isodon inflexus

作者：Xie, Wei-Dong^*; Li, Xia; Zhao, Jiang-He; Liu, Yong-Heng; Row, Kyung Ho

来源：Phytochemistry, 2012, 81: 153-158.

DOI：10.1016/j.phytochem.2012.05.033

• Isodon inflexus
• Lamiaceae
• Diterpenoid
• Abietane
• Glycoside
• Nitric oxide

Four abietane diterpenoids, inflexanin C, inflexanin D, inflexuside A and inflexuside B, were isolated from the aerial parts of Isodon inflexus. Their respective structures were established by NMR, mass spectrometry and CD as (+)-(1S,4R,5S,7S,8S,10S,13S)-1,7,18-trihydroxy-abieta-9(11)-ene-12-one 1-monoacetate, (+)-(1S,4R,5S,10S,13S)-1,18-dihydroxy-abieta-7,9(11)-diene-12-one 1-monoacetate, (-)-(1S,5S,10S,11R, 13R)-1,11,13-trihydroxy-abieta-8-ene-7-one 1-O-beta-D-glucopyranoside and (-)-(1S,5S,10S,11R,13R)-1,11,13-trihydroxy-abieta-8-ene-7-one 1-O-(2-O-coumaroyl)-beta-D-glucopyranoside. All compounds showed strong inhibitory activity against nitric oxide (NO) production in RAW264.7 lipopolysaccaride (LPS)-activated macrophages.

• 出版日期2012-9
• 单位山东大学