Novel chiral thioureas for highly enantioselective Michael reactions of malonates to nitroalkenes

作者：Yan Li Jun; Liu Quan Zhong^*; Wang Xue Lian

来源：Chinese Chemical Letters, 2009, 20(3): 310-313.

DOI：10.1016/j.cclet.2008.11.021

• Michael addition
• Thiourea
• Enantioselectivities
• Nitroalkene and malonate

Highly efficient Michael addition reactions of malonates to nitroalkenes catalyzed by novel chiral thioureas derived from optically pure BINOL and amino acids are reported. Various trans-nitroalkenes reacted with malonates affording the desired products in up to 95% yield with excellent enantioselectivities (up to 97% ee).

• 出版日期2009-3
• 单位西华师范大学