Autoimmune conditions and chronic infections in chronic lymphocytic leukemia patients at diagnosis are associated with unmutated IgV(H) genes

作者：Vanura Katrina; Le Trang; Esterbauer Harald; Spaeth Florentin; Porpaczy Edit; Shehata Medhat; Eigenberger Karin; Hauswirth Alexander; Skrabs Cathrin; Kroemer Elisabeth; Schwarzinger Ilse; Streubel Berthold; Steininger Christoph; Fonatsch Christa; Stilgenbauer Stephan; Wagner Oswald; Gaiger Alexander; Jaeger Ulrich

来源：Haematologica-The Hematology Journal, 2008, 93(12): 1912-1916.

DOI：10.3324/haematol.12955

• chronic lymphocytic leukemia
• chronic antigenic stimulation
• IgV(H) mutation status
• cytogenetics

Few data are available concerning the prevalence of autoimmune disease or chronic infections in chronic lymphocytic leukemia patients at diagnosis as well as their clinical outcome. We studied the frequency of such chronic conditions in relation to prognostic markers. A history of autoimmune disease or chronic infection was found in 21% of 186 chronic lymphocytic leukemia patients (12% in autoimmune diseases, 9% in chronic infections). Patients with a history of chronic stimulation were more likely to have unmutated IgV(H) genes (p<0.002), unfavorable or intermediate risk cytogenetics (11q, 17p deletions, trisomy 12) (p<0.001), and higher CD38 expression (p=0.004). Autoimmune conditions (n=22) were characterized by female predominance (55.0%) with a high frequency of unmutated IgV(H) (53,8%). Median time to first treatment was 83 months for the chronic stimulation group compared to 128 months for the non-chronic stimulation group (n.s.). Patients suffering from chronic conditions at chronic lymphocytic leukemia diagnosis are likely to have poor prognostic markers, particularly unmutated IgV(H) genes.

• 出版日期2008-12
• 单位河北医科大学