Anterior Ocular Biometry Using 3-Dimensional Optical Coherence Tomography

作者：Fukuda Shinichi^*; Kawana Keisuke; Yasuno Yoshiaki; Oshika Tetsuro

来源：Ophthalmology, 2009, 116(5): 882-889.

DOI：10.1016/j.ophtha.2008.12.022

Purpose: To evaluate anterior ocular biometry by comparing the measurements of central corneal thickness (CCT) and anterior chamber depth (ACD) with 3-dimensional corneal and anterior segment optical coherence tomography (CAS-OCT) and other methods.
Design: Cross-sectional study.
Participants: Forty eyes of 40 normal subjects.
Methods: The CCT was measured by 4 methods (CAS-OCT, Scheimpflug camera, scanning-slit topography, and ultrasonic pachymetry), and the ACD was measured by 3 methods (CAS-OCT, Scheimpflug camera, and scanning-slit topography). The anterior chamber volume (ACV) was calculated with CAS-OCT. Repeatability and reproducibility of CAS-OCT measurements were evaluated.
Main Outcome Measurements: The CCT and ACD were measured and compared between devices. The ACV was calculated with CAS-OCT. Coefficient of variation and intraclass correlation coefficient (ICC) were calculated to evaluate repeatability and reproducibility of CAS-OCT measurements.
Results: The mean CCT was 547.0 +/- 39.0, 590.0 +/- 39.8, 525.0 +/- 45.0, and 545.0 +/- 40.3 mu m with CAS-OCT, Scheimpflug camera, scanning-slit topography, and ultrasonic pachymetry, respectively. Significant differences were observed among the 4 methods (P<0.0001; 1-way analysis of variance [ANOVA]). The CCT measured with Scheimpflug camera was significantly larger than those measured with the other methods (P<0.0001; Bonferroni multiple comparison), but there was no significant difference among the other 3 methods. The mean ACD was 3.01 +/- 0.47, 3.04 +/- 0.52, and 2.88 +/- 0.50 mm with CAS-OCT, Scheimpflug camera, and scanning-slit topography, respectively. There was no significant difference among the 3 methods (P = 0.678; 1-way ANOVA). A significant linear correlation in CCT and ACD were observed between CAS-OCT and other methods (all P<0.0001). The mean ACV calculated with CAS-OCT was 169.7 +/- 23.1 mm(3). The coefficient of repeatability and reproducibility of CCT and ACD measurements were <5% and ICCs were >0.98.
Conclusions: The CCT measurements were comparable among CAS-OCT, ultrasonic pachymetry, and scanning-slit topography, but Scheimpflug camera yielded a significantly higher CCT value. There was no significant difference in ACD measurements among CAS-OCT, Scheimpflug camera, and scanning-slit topography. The ACV was noninvasively measured by CAS-OCT.
Financial Disclosure(s): The authors have no proprietary or commercial interest in any materials discussed in this article.

• 出版日期2009-5