A Vasodilating beta(1) Blocker Celiprolol Inhibits Muscular Release of Uric Acid Precursor in Patients with Essential Hypertension

作者：Mizuta E; Utami S B; Ohtahara A; Endo S; Mishima M; Hasegawa A; Yamada K; Kato M; Yamamoto K; Ogino K; Ninomiya H; Miyazaki S; Hamada T^*; Taniguchi S I; Cheng J; Hisatome I

来源：Hormone and Metabolic Research, 2013, 45(1): 69-73.

DOI：10.1055/s-0032-1321872

• hypoxanthine
• celiprolol
• myogenic hyperuricemia
• hypertension
• exercise

Although nonvasodilating beta 1 blockers increase the levels of uric acid in serum, it is not known whether vasodilating beta 1 blockers have a similar effect. In the present study, we evaluated the effect of celiprolol on the release of hypoxanthine, a uric acid precursor, from muscles after an exercise. We used the semi-ischemic forearm test to examine the release of lactate (Delta LAC), ammonia (Delta Amm), and hypoxanthine (Delta HX) before and 4, 10, and 60 min after an exercise in 18 hypertensive patients as well as 4 normotensive subjects. Before celiprolol treatment, all the levels of Delta HX and Delta Amm, and Delta LAC were increased by semi-ischemic exercise in hypertensive patients, and the increases were remarkably larger than those in normotensive subjects. Celiprolol decreased both systolic and diastolic pressure. It also decreased the levels of Delta HX and Delta Amm without changes in Delta LAC after an exercise. These findings also were confirmed by summation of each metabolite (Sigma Delta Metabolites). Celiprolol caused a marginal decrease of serum uric acid, but the difference was not statistically significant. On the other hand, nonvasodilating beta 1 blockers did not suppress the levels of Delta HX and Delta Amm, whereas they significantly increased Delta LAC after an exercise. Celiprolol improved energy metabolism in skeletal muscles. It suppressed HX production and consequently did not adversely affect serum uric acid levels.

• 出版日期2013-1
• 单位汕头大学