High resolution three-dimensional photoacoustic imaging of human finger joints in vivo

作者：Xi, Lei^*; Jiang, Huabei

来源：Applied Physics Letters, 2015, 107(6): 063701.

DOI：10.1063/1.4926859

• TOMOGRAPHY
• OSTEOARTHRITIS
• DIAGNOSIS

We present a method for noninvasively imaging the hand joints using a three-dimensional (3D) photoacoustic imaging (PAI) system. This 3D PAI system utilizes cylindrical scanning in data collection and virtual-detector concept in image reconstruction. The maximum lateral and axial resolutions of the PAI system are 70 mu m and 240 mu m. The cross-sectional photoacoustic images of a healthy joint clearly exhibited major internal structures including phalanx and tendons, which are not available from the current photoacoustic imaging methods. The in vivo PAI results obtained are comparable with the corresponding 3.0 T MRI images of the finger joint. This study suggests that the proposed method has the potential to be used in early detection of joint diseases such as osteoarthritis.

• 出版日期2015-8-10
• 单位电子科技大学