A dimeric mutant of human pancreatic ribonuclease with selective cytotoxicity toward malignant cells

作者：Piccoli R; Di Gaetano S; De Lorenzo C; Grauso M; Monaco C; Spalletti Cernia D; Laccetti P; Cinatl J; Matousek J; D'Alessio G^*

来源：Proceedings of the National Academy of Sciences of the United States of America, 1999, 96(14): 7768-7773.

DOI：10.1073/pnas.96.14.7768

Monomeric human pancreatic RNase, devoid of any biological activity other than its RNA degrading ability, was engineered into a dimeric protein with a cytotoxic action on mouse and human tumor cells, but lacking any appreciable toxicity on mouse and human normal cells. This dimeric variant of human pancreas RNase selectively sensitizes to apoptotic death cells derived from a human thyroid tumor. Because of its selectivity for tumor cells, and because of its human origin, this protein represents a potentially very attractive, novel tool for anticancer therapy.

• 出版日期1999-7-6