科研之友
微信
新浪微博
Facebook
分享链接
摘要
Background: Interleukin-22 (IL-22) is a member of the IL-10 family of anti-inflammatory cytokines that mediates epithelial immunity. IL-22 expression was found to be increased in patients with ulcerative colitis (UC). Whether genetic polymorphisms of IL-22 also influence UC risk is still unknown. The purpose of this study was to investigate the association between the IL-22 gene polymorphisms (-429 C/T, + 1046 T/A and + 1995 A/C) and the risk of UC in Chinese Han patients. Methods: This hospital-based case-control study comprised 180 patients with UC and 180 age-and gender-matched controls. Genotypes of 3 common polymorphisms of the IL-22 gene were determined by fluorogenic 5 ' exonuclease assays (TaqMan). Results: Patients with UC had a significantly higher frequency of IL-22 -429 TT genotype [odds ratio (OR) = 2.43, 95% confidence interval (CI) = 1.35, 4.37; P = 0.003] and -429 T allele (OR = 1.54, 95% CI = 1.14, 2.07; P = 0.004) than controls. The findings are still emphatic by the Bonferroni correction. The IL-22 + 1046 T/A and IL-22 + 1995 A/C gene polymorphisms were not associated with a risk of UC. When stratifying by clinical type, location and disease severity of UC, no significant differences were found in any groups. Conclusion: This is the first study to provide evidence for an association of IL-22 -429 C/T gene polymorphisms with UC risk. Additional well-designed large studies were required for the validation of our results. Virtual Slides: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/ 13000_2014_183
