A GTPase switch maintains CENP-A at centromeric chromatin

作者:Prendergast Lisa*; Sullivan Kevin F
来源:Nature Cell Biology, 2010, 12(12): 1128-1130.
DOI:10.1038/ncb1210-1128

摘要

The histone H3 variant CENP-A defines centromeric chromatin, but it has been unclear how CENP-A is stably maintained at centromeres. It has now been shown that the CENP-A licensing factor HsKNL2 and the small GTPases activating protein MgcRacGAP cooperate to promote the stability of newly loaded CENP-A at centromeres.

  • 出版日期2010-12