Dimorphisms of NPY2R gene unassociated with alcohol dependence in Chinese Han population

作者：Kang, Yimin; Wang, Fan; Li, Cunbao; Hu, Lufeng; Xu, Jinzhong; Tan, Xiaohua; Wang, Xiaofang; Lin, Hong; Wang, Pengxiang; Zuo, Wei; Xie, Longteng; Qiu, Guoshi; Jiang, Yongsheng; Xin, Yan^*; Liu, Yanlong^*

来源：International Journal of Clinical and Experimental Medicine, 2016, 9(2): 4527-4532.

• NPY
• alcohol dependence
• polymorphism

Objective: Excessive and chronic alcohol use has been associated with damage to major organs and is a leading cause of death in industrialized countries. Research has indicated that alcohol dependence (AD) is related to both heritable and environmental factors. Previous studies have suggested that neuropeptide Y receptors (NPYR) are associated with AD, however, few studies have investigated the associations between NPY2R gene variants and AD in detail. The present study evaluated the association between NPY2R gene variations and AD in a genetically homogeneous Chinese Han population. Methods: All of AD patients were diagnosed using Diagnostic and Statistical Manual of Mental Disorders, 4th Edition criteria, and the two single nucleotide polymorphisms (SNPs) of NPY2R were genotyped in healthy controls (n = 633) and AD patients (n = 547) using the TaqManTM probe. The two SNPs selected, rs6857715 and rs4425326, were located on the 5'-flanking region of NPY2R. Results: The allele and genotype frequencies of all loci did not significantly differ between controls and AD patients (P > 0.05). Interestingly, linkage disequilibrium analysis revealed that one possible haplotype is present between in rs6857715 and rs4425326 on NPY2R gene (D' = 0.974, r2 = 0.488). Conclusion: These results suggest that the two SNPs of the NPY2R gene do not play a role in the northern Chinese Han population with AD.

• 出版日期2016
• 单位北京回龙观医院; 北京大学; 内蒙古医科大学; 温州医科大学