Maternal insulin-like growth factors 1 and 2 (IGF-1, IGF-2) and IGF BP-3 and the hypertensive disorders of pregnancy

作者：Cooley Sharon M^*; Donnelly Jennifer C; Geary Michael P; Rodeck Charles H; Hindmarsh Peter C

来源：Journal of Maternal-Fetal and Neonatal Medicine, 2010, 23(7): 658-661.

DOI：10.3109/14767050903301033

• Pre-eclampsia
• insulin-like growth factor
• insulin-like growth factor binding protein
• gestational hypertension

Objective. To investigate the relationship between levels of insulin-like growth factors 1 and 2 (IGF-1, IGF-2) and insulin-like growth factor binding protein 3 (IGFBP-3) in antenatal maternal serum and gestational hypertension and pre-eclampsia ( PET).
Methods. Prospective cohort study of 1650 low-risk Caucasian women in a University teaching hospital in London. Statistical analysis was performed using commercial software (SPSS for Windows, version 6.1, SPSS, Chicago, IL), with P < 0.05 as significant. Maternal IGF 1, IGF 2 and IGF BP-3 were assessed on maternal blood at booking. Blood pressure was checked at each visit in conjunction with urine analysis. The Davey & MacGillivray 1988 classification system was used in making the diagnosis of PET.
Results. There was no significant correlation between maternal IGF-1 or IGFBP-3 levels and gestational hypertension or PET. However, a significant positive correlation does exist between maternal IGF-2 levels and PET.
Conclusions. Maternal IGF-2 has a significant positive correlation with PET.

• 出版日期2010-7